Services
Production of Genetically Engineered Mice:
Click on links below to access service request forms and service descriptions
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We will inject your transgene expression construct DNA
into zygote pronuclei to produce Transgenic Mice by gene transfer |
$2200 |
Knockout/Knockin Mice Generation: We will inject your targeted embryonic stem cells into
blastocysts to produce Knockout or Knockin Mice |
$2200 |
Embryo Shipping or Importation / Mouse Line Preservation : We are in the process of establishing regular services for embryo cryopreservation, embryo reconstitution, and mouse line rederivation. Please contact us if you need these services, or might need them in future. |
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The MMC uses only Specific Pathogen Free + Mice
A goal of the Mouse Models Core (MMC) is to keep the mice that we generate for investigators as disease free as possible. Therefore, the MMC will only purchase from certified vendors mouse strains that, in addition to testing negative for the pathogens routinely screened by ACS, are Helicobacter-free and Norovirus-free. Helicobacter (spp.) and Murine Norovirus 1 are prevalent in many “Specific Pathogen Free” (SPF) facilities and can have effects on mouse phenotypes. All MMC mice will be produced in a dedicated suite, with access strictly limited to MMC personnel, in the Cancer and Genetics Research Complex SPF rodent facility. The SPF+ MMC will be a step above the regular SPF facility in regards to pathogen exclusion. Embryo donors, embryo recipients, and stud mice will be bred on site, with frequent, regular re-stocking from certified vendors to maintain strain integrity. All racks are monitored for pathogens using sentinel mice that are tested every 3 months.
